Article
The relationship between riboflavin and plasma total homocysteine in the Framingham Offspring cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate reductase gene.
The Journal of nutrition - 1 Feb 2002
Jacques Paul F, Kalmbach Renee, Bagley Pamela J, Russo Giuseppina T, Rogers Gail, Wilson Peter W F, Rosenberg Irwin H, Selhub Jacob
Abstract excerpt
Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate, the methyl donor for remethylation of homocysteine to methionine. The C677T MTHFR polymorphism is associated with mild hyperhomocysteinemia, but only in the presence of low folate status. Because MTHFR contains flavin adenine dinucleotide (FAD) as a prosthetic group, riboflavin status may also influence homocysteine...
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