Article
Methylenetetrahydrofolate reductase 677C-->T variant modulates folate status response to controlled folate intakes in young women.
The Journal of nutrition - 1 May 2003
Guinotte Cheryl L, Burns Michael G, Axume Juan A, Hata Hiroko, Urrutia Tania F, Alamilla Aaron, McCabe Dale, Singgih Anny, Cogger Edward A, Caudill Marie A
Abstract excerpt
A common genetic variant in the methylenetetrahydrofolate reductase (MTHFR) gene involving a cytosine to thymidine (C-->T) transition at nucleotide 677 is associated with reduced enzyme activity, altered folate status and potentially higher folate requirements. The objectives of this study were to investigate the effect of the MTHFR 677 T allele on folate status variables in Mexican women (n = 43; 18-45 y) and to...
Topics
- Adult
- Base Sequence
- California
- Erythrocytes
- Female
- Folic Acid
- Folic Acid Deficiency
- Gene Deletion
- Genetic Variation
- Genotype
- Hispanic or Latino