Article
Choline intake, plasma riboflavin, and the phosphatidylethanolamine N-methyltransferase G5465A genotype predict plasma homocysteine in folate-deplete Mexican-American men with the methylenetetrahydrofolate reductase 677TT genotype.
The Journal of nutrition - 1 Apr 2009
Caudill Marie A, Dellschaft Neele, Solis Claudia, Hinkis Sabrina, Ivanov Alexandre A, Nash-Barboza Susan, Randall Katharine E, Jackson Brandi, Solomita Gina N, Vermeylen Francoise
Abstract excerpt
We previously showed that provision of the folate recommended dietary allowance and either 300, 550, 1100, or 2200 mg/d choline for 12 wk resulted in diminished folate status and a tripling of plasma total homocysteine (tHcy) in men with the methylenetetrahydrofolate reductase (MTHFR) 677TT genotype. However, the substantial variation in tHcy within the 677TT genotype at wk 12 implied that several factors were...
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