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Article

Genetic polymorphisms and folate status.

Congenital anomalies - 1 Sept 2017

Hiraoka Mami, Kagawa Yasuo

Abstract excerpt

Moderate hyperhomocysteinemia-induced low folate status is an independent risk factor for cardiovascular disease, dementia, and depression. Folate is an essential cofactor in the one-carbon metabolism pathway and is necessary in amino acid metabolism, purine and thymidylate synthesis, and DNA methylation. In the folate cycle and homocysteine metabolism, folate, vitamin B12, vitamin B6, and vitamin B2 are...

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Source

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Identifiers

PMID: 28598562
DOI: 10.1111/cga.12232
PMCID: PMC5601299

Genes

MTHFR

Variants

Provenance

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