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Article

Chromosome instability in lymphocytes: a potential indicator of predisposition to oral premalignant lesions.

Cancer research - 15 May 2002

Wu Xifeng, Lippman Scott M, Lee J Jack, Zhu Yong, Wei Q Victoria, Thomas Margaret, Hong Waun Ki, Spitz Margaret R

Abstract excerpt

Oral premalignant lesions (OPLs) are related to tobacco use and mark individuals at high risk for oral cancer development. Increased mutagen sensitivity as measured by an in vitro mutagen challenge assay has been shown to be a risk factor for upper aerodigestive tract cancers. In this case control study, we used two assays with mutagens relevant to tobacco exposure (benzo[a]pyrene diol epoxide (BPDE) and...

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PMID: 12019158

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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