Article
Sensitivity to benzo(a)pyrene diol-epoxide associated with risk of breast cancer in young women and modulation by glutathione S-transferase polymorphisms: a case-control study.
Cancer research - 1 Dec 2001
Xiong P, Bondy M L, Li D, Shen H, Wang L E, Singletary S E, Spitz M R, Wei Q
Abstract excerpt
Mounting epidemiological evidence suggests that smoking may play a role in the etiology of breast cancer. Because smoking-related DNA adducts are detectable in both normal and malignant breast tissues, we hypothesized that breast cancer patients may be sensitive to tobacco-induced carcinogenesis, and this sensitivity could be modulated by variants of metabolic genes. To test this hypothesis, we evaluated...
Topics
- 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
- Adult
- Breast Neoplasms
- Carcinogens
- Case-Control Studies
- Chromosome Aberrations
- Cocarcinogenesis
- Female
- Genetic Predisposition to Disease
- Glutathione Transferase