BPDE-induced lymphocytic 3p21.3 aberrations may predict head and neck carcinoma risk.

doi:10.1002/cncr.10689

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Article

BPDE-induced lymphocytic 3p21.3 aberrations may predict head and neck carcinoma risk.

Cancer - 1 Aug 2002

Zhu Yong, Spitz Margaret R, Zheng Yun-Ling, Hong Waun K, Wu Xifeng

Abstract excerpt

BACKGROUND: Tobacco exposure is an established risk factor for head and neck squamous cell carcinoma (HNSCC). Benzo[alpha]pyrene diol expoxide (BPDE), a main metabolic product of the tobacco smoke constituent benzo[alpha]pyrene, induces chromosomal aberrations at specific loci. Chromosomal aberrations in peripheral blood lymphocytes (PBLs) induced by BPDE may reflect individuals' genetic susceptibility to tobacco...

Topics

7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Aged
Carcinogens
Carcinoma, Squamous Cell
Chromosome Aberrations
Chromosomes, Human, Pair 3
Female
Genetic Predisposition to Disease
Genetic Testing
Head and Neck Neoplasms
Humans
In Situ Hybridization, Fluorescence
Lymphocytes
Male
Middle Aged
Predictive Value of Tests

Source

Open in PubMed

Identifiers

PMID: 12209748
DOI: 10.1002/cncr.10689

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