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Article

Targeting of lung cancer mutational hotspots by polycyclic aromatic hydrocarbons.

Journal of the National Cancer Institute - 17 May 2000

Smith L E, Denissenko M F, Bennett W P, Li H, Amin S, Tang M, Pfeifer G P

Abstract excerpt

BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in combustion products of organic matter, including cigarette smoke. Metabolically activated diol epoxides of these compounds, including benzo[a]pyrene diol epoxide (B[a]PDE), have been suggested as causative agents in the development of lung cancer. We previously mapped the distribution of B[a]PDE adducts within the p53 tumor suppressor gene...

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Identifiers

PMID: 10814675
DOI: 10.1093/jnci/92.10.803

Genes

PAH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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