Sensitivity to DNA damage induced by benzo(a)pyrene diol epoxide and risk of lung cancer: a case-control analysis.

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Article

Sensitivity to DNA damage induced by benzo(a)pyrene diol epoxide and risk of lung cancer: a case-control analysis.

Cancer research - 15 Feb 2001

Li D, Firozi P F, Wang L E, Bosken C H, Spitz M R, Hong W K, Wei Q

Abstract excerpt

Levels of DNA adducts vary greatly in vivo, attributable to individual differences in enzymatic bioactivation of benzo(a)pyrene. We developed an assay to measure the levels of DNA adducts induced in vitro by benzo(a)pyrene diol epoxide (BPDE), a bioactivated form of benzo(a)pyrene. In this large...

Topics

7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Carcinogens
Case-Control Studies
DNA Adducts
DNA Damage
DNA Repair
Female
Genetic Predisposition to Disease
Humans
Lung Neoplasms
Male
Middle Aged

Source

Open in PubMed

Identifiers

PMID: 11245449

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-11245449-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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