Article
Activation of platelet-derived growth factor receptor alpha contributes to liver fibrosis.
PloS one - 1 Jan 2014
Hayes Brian J, Riehle Kimberly J, Shimizu-Albergine Masami, Bauer Renay L, Hudkins Kelly L, Johansson Fredrik, Yeh Matthew M, Mahoney William M, Yeung Raymond S, Campbell Jean S
Abstract excerpt
Chronic liver injury leads to fibrosis, cirrhosis, and loss of liver function. Liver cirrhosis is the 12th leading cause of death in the United States, and it is the primary risk factor for developing liver cancer. Fibrosis and cirrhosis result from activation of hepatic stellate cells (HSCs), which are the primary collagen producing cell type in the liver. Here, we show that platelet-derived growth factor...
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