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Article

A conserved pathway of transdifferentiation in murine Kupffer cells.

European journal of immunology - 1 Oct 2021

Li Xinyu, Hollingshead Nicole, Lampert Sarah, Truong Camtu D, Li Wanyu, Niu Junqi, Crispe Ian N, Soysa Radika

Abstract excerpt

Abundant long-lived liver-resident macrophages, termed Kupffer cells, are activated during chronic liver injury. They secrete both pro-inflammatory and pro-fibrotic cytokines, which act on hepatic stellate cells causing their transdifferentiation into myofibroblasts that deposit collagen. In other tissues, wound-associated macrophages go further, and transdifferentiate into fibrocytes, secreting collagen...

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Identifiers

PMID: 34324208
DOI: 10.1002/eji.202049124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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