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Article

DNase I-hypersensitive sites enhance α1(I) collagen gene expression in hepatic stellate cells

1 Feb 2003

Abstract excerpt

Liver fibrosis is characterized by a dramatic increase in the expression of type I collagen. Several deoxyribonuclease (DNase) I-hypersensitive sites (HS) have been located in the distal 5'-flanking region of the alpha1(I) collagen gene that are specific to collagen-producing cells. To assess the role of the DNase I-HS in regulating alpha1(I) collagen gene expression in hepatic stellate cells (HSCs), 3 transgenic...

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Identifiers

PMID: 12540776
DOI: 10.1053/jhep.2003.50067

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