Article
Activation of Rac1 promotes hedgehog-mediated acquisition of the myofibroblastic phenotype in rat and human hepatic stellate cells.
Hepatology (Baltimore, Md.) - 1 Jul 2010
Choi Steve S, Witek Rafal P, Yang Liu, Omenetti Alessia, Syn Wing-Kin, Moylan Cynthia A, Jung Youngmi, Karaca Gamze F, Teaberry Vanessa S, Pereira Thiago A, Wang Jiangbo, Ren Xiu-Rong, Diehl Anna Mae
Abstract excerpt
UNLABELLED: Hepatic accumulation of myofibroblastic hepatic stellate cells (MF-HSCs) is pivotal in the pathogenesis of cirrhosis. Two events are necessary for MF-HSCs to accumulate in damaged livers: transition of resident, quiescent hepatic stellate cells (Q-HSCs) to MF-HSCs and expansion of MF-HSC numbers through increased proliferation and/or reduced apoptosis. In this study, we identified two novel mediators...
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