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Article

Myocardin‐related transcription factor A drives ROS‐fueled expansion of hepatic stellate cells by regulating p38‐MAPK signalling

1 Feb 2022

Abstract excerpt

We describe in this letter a novel retrograde signalling mechanism that highlights a myofibroblast-specific role for myocardin-related transcription factor A (MRTF-A), also known as MKL1, in liver fibrosis. Liver fibrosis is considered a common pathological process in virtually all end-stage liver diseases. Absent from the liver under physiological conditions, myofibroblasts quickly emerge and expand as a result...

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PMID: 35184409
DOI: 10.1002/ctm2.688

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