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Hepatic stellate cell–specific knockout of transcriptional intermediary factor 1γ aggravates liver fibrosis

8 Apr 2020

Abstract excerpt

Transforming growth factor β (TGFβ) is a crucial factor in fibrosis, and transcriptional intermediary factor 1γ (TIF1γ) is a negative regulator of the TGFβ pathway; however, its role in liver fibrosis is unknown. In this study, mesenchymal stem cells derived from human embryonic stem cells (hE-MSCs) that secrete hepatocyte growth factor (HGF) were used to observe the repair of thioacetamide (TAA)-induced liver...

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PMID: 32267915
DOI: 10.1084/jem.20190402

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