Article
The myofibroblastic conversion of peribiliary fibrogenic cells distinct from hepatic stellate cells is stimulated by platelet-derived growth factor during liver fibrogenesis.
Laboratory investigation; a journal of technical methods and pathology - 1 Feb 2003
Kinnman Nils, Francoz Claire, Barbu Véronique, Wendum Dominique, Rey Colette, Hultcrantz Rolf, Poupon Raoul, Housset Chantal
Abstract excerpt
The origin of myofibroblasts and the factors promoting their differentiation during liver fibrogenesis remain uncertain. During biliary-type fibrogenesis, the proliferation and chemoattraction of hepatic stellate cells (HSC) toward bile ducts is mediated by platelet-derived growth factor (PDGF), while myofibroblastic conversion of peribiliary cells distinct from HSC also occurs. We herein examined the phenotype...
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