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Article

Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila.

Nature communications - 8 Jun 2020

Meir Amit, Macé Kevin, Lukoyanova Natalya, Chetrit David, Hospenthal Manuela K, Redzej Adam, Roy Craig, Waksman Gabriel

Abstract excerpt

Legionella pneumophila is a bacterial pathogen that utilises a Type IV secretion (T4S) system to inject effector proteins into human macrophages. Essential to the recruitment and delivery of effectors to the T4S machinery is the membrane-embedded T4 coupling complex (T4CC). Here, we purify an intact T4CC from the Legionella membrane. It contains the DotL ATPase, the DotM and DotN proteins, the chaperone module...

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Identifiers

PMID: 32513920
DOI: 10.1038/s41467-020-16681-z
PMCID: PMC7280309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila.PMID 32513920Read ↗

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