Article
The Legionella pneumophila IcmS-LvgA protein complex is important for Dot/Icm-dependent intracellular growth.
Molecular microbiology - 1 Aug 2006
Vincent Carr D, Vogel Joseph P
Abstract excerpt
Many bacterial pathogens require a functional type IV secretion system (T4SS) for virulence. Legionella pneumophila, the causative agent of Legionnaires' disease, employs the Dot/Icm T4SS to inject a large number of protein substrates into its host, thereby altering phagosome trafficking. The L. pneumophila T4SS substrate SdeA has been shown to require the accessory factor IcmS for its export. IcmS, defined as a...
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