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Article

The Coxiella burnetii Dot/Icm system delivers a unique repertoire of type IV effectors into host cells and is required for intracellular replication.

PLoS pathogens - 1 May 2011

Carey Kimberly L, Newton Hayley J, Lührmann Anja, Roy Craig R

Abstract excerpt

Coxiella burnetii, the causative agent of human Q fever, is an intracellular pathogen that replicates in an acidified vacuole derived from the host lysosomal network. This pathogen encodes a Dot/Icm type IV secretion system that delivers bacterial proteins called effectors to the host cytosol. To identify new effector proteins, the functionally analogous Legionella pneumophila Dot/Icm system was used in a genetic...

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PMID: 21637816
DOI: 10.1371/journal.ppat.1002056
PMCID: PMC3102713

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