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Article

Native structure of a type IV secretion system core complex essential for <i>Legionella</i> pathogenesis

25 Jul 2014

Abstract excerpt

Bacterial type IV secretion systems are evolutionarily related to conjugation systems and play a pivotal role in infection by delivering numerous virulence factors into host cells. Using transmission electron microscopy, we report the native molecular structure of the core complex of the Dot/Icm type IV secretion system encoded by Legionella pneumophila, an intracellular human pathogen. The biochemically isolated...

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PMID: 25062693
DOI: 10.1073/pnas.1404506111

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Native structure of a type IV secretion system core complex essential for <i>Legionella</i> pathogenesisPMID 25062693Read ↗

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