Article
Frequent silencing of fragile histidine triad gene (FHIT) in Burkitt's lymphoma is associated with aberrant hypermethylation.
Genes, chromosomes & cancer - 1 Dec 2004
Hussain Azhar, Gutiérrez Marina I, Timson Georgina, Siraj Abdul K, Deambrogi Clara, Al-Rasheed Maha, Gaidano Gianluca, Magrath Ian, Bhatia Kishor
Abstract excerpt
The fragile histidine triad (FHIT) gene, a potential tumor-suppressor gene, is frequently inactivated in multiple human cancers. However, the FHIT gene remains largely unexplored in Burkitt's lymphoma (BL). Hence, we assessed whether loss of FHIT expression occurs in BL, and, if so, what is the mechanism of such loss. Lack of protein expression was observed in 50% of BL cell lines. Methylation-specific polymerase...
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