Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aberrant methylation of the FHIT gene in chronic smokers with early stage squamous cell carcinoma of the lung

3 Jun 2004

Abstract excerpt

Fragile histidine triad (FHIT) gene plays an important role in the pathogenesis of lung cancer. However, the clinicopathological significance of CpG island hypermethylation of FHIT gene in non-small cell lung cancer (NSCLC) remains to be elucidated. We studied FHIT methylation in 254 NSCLCs in order to further understand the clinicopathological and prognostic significance of FHIT methylation in NSCLC. Methylation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Childhood Cancer Survivors' Quality of Life
Share to Epigenetics and DNA Methylation
Share to Genetics and Neurodevelopmental Disorders

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15231689
DOI: 10.1093/carcin/bgh217

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aberrant methylation of the FHIT gene in chronic smokers with early stage squamous cell carcinoma of the lungPMID 15231689Read ↗

Quantitative assessment of the diagnostic role of FHIT promoter methylation in non-small cell lung cancer.Semantic proximity Read ↗

Aberration of FHIT gene is associated with increased tumor proliferation and decreased apoptosis-clinical evidence in lung and head and neck carcinomas.Semantic proximity Read ↗

Allelic deletion analysis of the FHIT gene predicts poor survival in non-small cell lung cancer.Semantic proximity Read ↗

[Alterations of FHIT gene and p16 gene in lung cancer and metastatic hilar lymph nodes].Semantic proximity Read ↗

Mutation analysis of the FHIT gene in bronchoscopic specimens from patients with suspected lung cancer.Semantic proximity Read ↗

Frequent allelic deletion at the FHIT locus associated with p53 overexpression in squamous cell carcinoma subtype of Taiwanese non-small-cell lung cancers.Semantic proximity Read ↗

The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinomaSemantic proximity Read ↗

Do FHIT gene alterations play a role in human solid tumors?Semantic proximity Read ↗

Genome-wide analysis of DNA methylation in bronchial washingsSemantic proximity Read ↗

Inverse correlation between EGFR mutation and FHIT, RASSF1A and RUNX3 methylation in lung adenocarcinoma: relation with smoking status.Semantic proximity Read ↗

A low DNA methylation epigenotype in lung squamous cell carcinoma and its association with idiopathic pulmonary fibrosis and poorer prognosisSemantic proximity Read ↗

FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.