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Article

Aberrant expression and deletion of FHIT gene in leukemias.

Zhongguo shi yan xue ye xue za zhi - 1 Apr 2003

Wang Li, Dong Lu-Jia, Tian Fang, Liu Guang-Xian, Li Chun-Hai

Abstract excerpt

FHIT (fragile histidine triad) gene at chromosome 3p14.2 usually expresses at a very low level in human tissue and cells. A high frequency of abnormalities in FHIT gene has been demonstrated in various cancers. FHIT is proposed as a putative tumor-suppressor gene. To evaluate the expression of the FHIT gene in various leukemias, bone marrow or peripheral blood samples from 98 leukemia patients were tested by...

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Source

Identifiers

PMID: 12744737

Genes

FHIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aberrant expression and deletion of FHIT gene in leukemias.PMID 12744737Read ↗

Expression of aberrant functional and nonfunctional transcripts of the FHIT gene in Burkitt's lymphomas.Semantic proximity Read ↗

Anomalous transcripts and allelic deletions of the FHIT gene in human esophageal cancer.Semantic proximity Read ↗

Do FHIT gene alterations play a role in human solid tumors?Semantic proximity Read ↗

Alternative splicing, but not allelic loss, of the FHIT gene increases with development of lung cancer.Semantic proximity Read ↗

FHIT alterations in breast cancer.Semantic proximity Read ↗

FHITness and cancer.Semantic proximity Read ↗

Aberrant FHIT transcripts in squamous cell carcinoma of the uterine cervix.Semantic proximity Read ↗

Expression and methylation status of the FHIT gene in acute myeloid leukemia and myelodysplastic syndromeSemantic proximity Read ↗

Evaluation of the FHIT gene in colorectal cancers.Semantic proximity Read ↗

Aberration of FHIT gene is associated with increased tumor proliferation and decreased apoptosis-clinical evidence in lung and head and neck carcinomas.Semantic proximity Read ↗

Frequent silencing of fragile histidine triad gene (FHIT) in Burkitt's lymphoma is associated with aberrant hypermethylation.Semantic proximity Read ↗

FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations.Semantic proximity Read ↗

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