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Article

Evidence for a novel GTPase priming step in the SRP protein targeting pathway.

The EMBO journal - 3 Dec 2001

Lu Y, Qi H Y, Hyndman J B, Ulbrandt N D, Teplyakov A, Tomasevic N, Bernstein H D

Abstract excerpt

Protein targeting by the signal recognition particle (SRP) pathway requires the interaction of two homologous GTPases that reciprocally regulate each other's GTPase activity, the SRP signal peptide- binding subunit (SRP54) and the SRP receptor alpha-subunit (SRalpha). The GTPase domain of both proteins abuts a unique 'N domain' that appears to facilitate external ligand binding. To examine the relationship...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11726508
DOI: 10.1093/emboj/20.23.6724
PMCID: PMC125757

Genes

SRP54

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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