Dual specificity of the interfacial inhibitor brefeldin a for arf proteins and sec7 domains.

Abstract excerpt

Guanine nucleotide exchange factors (GEFs), which activate small GTP-binding proteins (SMG) by stimulating their GDP/GTP exchange, are emerging as candidate targets for the inhibition of cellular pathways involved in diseases. However, their specific inhibition by competitive inhibitors is challenging, because GEF and SMG families comprise highly similar members. Nature shows us an alternative strategy called...

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• HeLa Cells
• ADP-Ribosylation Factors
• Brefeldin A
• Guanine Nucleotide Exchange Factors
• Protein Conformation