Article
Membrane binding of the bacterial signal recognition particle receptor involves two distinct binding sites.
The Journal of cell biology - 28 Aug 2006
Angelini Sandra, Boy Diana, Schiltz Emile, Koch Hans-Georg
Abstract excerpt
Cotranslational protein targeting in bacteria is mediated by the signal recognition particle (SRP) and FtsY, the bacterial SRP receptor (SR). FtsY is homologous to the SRalpha subunit of eukaryotes, which is tethered to the membrane via its interaction with the membrane-integral SRbeta subunit. Despite the lack of a membrane-anchoring subunit, 30% of FtsY in Escherichia coli are found stably associated with the...
Topics
- Bacterial Proteins
- Binding Sites
- Carbonates
- Endopeptidase K
- Enzyme Inhibitors
- Escherichia coli
- Escherichia coli Proteins
- Guanylyl Imidodiphosphate
- Intracellular Membranes
- Mutation
- Protein Binding
- Protein Structure, Tertiary
- Receptors, Cytoplasmic and Nuclear
- Receptors, Peptide