An IL-4R alpha allelic variant, I50, acts as a gain-of-function variant relative to V50 for Stat6, but not Th2 differentiation.

doi:10.4049/jimmunol.173.7.4523

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

An IL-4R alpha allelic variant, I50, acts as a gain-of-function variant relative to V50 for Stat6, but not Th2 differentiation.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2004

Stephenson Linda, Johns Mary H, Woodward Emily, Mora Ana L, Boothby Mark

Abstract excerpt

Signaling through the IL-4R alpha-chain (IL-4Ralpha) is crucial for the development of Th2 cells, central effectors in atopic disease. Alleles of the IL-4Ralpha have been identified that have been variably associated with increased incidence of allergic disease, but there is little direct evidence that any variant is sufficient to alter a target that determines allergic pathophysiology or susceptibility. Variants...

Topics

Alleles
Animals
Cell Differentiation
DNA-Binding Proteins
Genetic Variation
Growth Inhibitors
Humans
Interleukin-4
Interleukin-4 Receptor alpha Subunit
Isoleucine
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred BALB C

Mice, Inbred C57BL

Mice, Knockout

Mice, Transgenic

Mutagenesis, Site-Directed

Protein Subunits

Receptors, Cell Surface

Source

Open in PubMed

Identifiers

PMID: 15383584
DOI: 10.4049/jimmunol.173.7.4523

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An IL-4R alpha allelic variant, I50, acts as a gain-of-function variant relative to V50 for Stat6, but not Th2 differentiation.PMID 15383584Read ↗

The R576 IL-4 receptor alpha allele correlates with asthma severity.Semantic proximity Read ↗

Cutting edge: dominant effect of Ile50Val variant of the human IL-4 receptor alpha-chain in IgE synthesis.Semantic proximity Read ↗

Atopy and the human IL-4 receptor alpha chain.Semantic proximity Read ↗

Analysis of the Ser786Pro interleukin-4 receptor alpha allelic variant in allergic and nonallergic asthma and its functional consequences.Semantic proximity Read ↗

The polymorphisms S503P and Q576R in the interleukin-4 receptor alpha gene are associated with atopy and influence the signal transduction.Semantic proximity Read ↗

Interleukin-4 receptor alpha gene variants and allergic disease.Semantic proximity Read ↗

Cutting Edge: Dominant Effect of Ile50Val Variant of the Human IL-4 Receptor α-Chain in IgE SynthesisSemantic proximity Read ↗

Ile50Val variant of IL4Rα upregulates IgE synthesis and associates with atopic asthmaSemantic proximity Read ↗

Effects of common atopy-associated amino acid substitutions in the IL-4 receptor alpha chain on IL-4 induced phenotypes.Semantic proximity Read ↗

Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma.Semantic proximity Read ↗

Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation.Semantic proximity Read ↗

The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.