Article
The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor.
The New England journal of medicine - 11 Dec 1997
Hershey G K, Friedrich M F, Esswein L A, Thomas M L, Chatila T A
Abstract excerpt
BACKGROUND: Atopic diseases are very common, and atopy has a strong genetic predisposition. METHODS: Using single-strand conformation polymorphism analysis and DNA sequencing, we searched for mutations in the a subunit of the interleukin-4 receptor that would predispose persons to atopy. We exami...
Topics
- Adult
- Alleles
- Dermatitis, Atopic
- Flow Cytometry
- Humans
- Hypersensitivity, Immediate
- Immunoblotting
- Immunoglobulin E
- Point Mutation
- Polymorphism, Single-Stranded Conformational
- Receptors, Interleukin-4
- Signal Transduction