Article
The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor.
The New England journal of medicine - 11 Dec 1997
Hershey G K, Friedrich M F, Esswein L A, Thomas M L, Chatila T A
Abstract excerpt
BACKGROUND: Atopic diseases are very common, and atopy has a strong genetic predisposition. METHODS: Using single-strand conformation polymorphism analysis and DNA sequencing, we searched for mutations in the a subunit of the interleukin-4 receptor that would predispose persons to atopy. We examined the prevalence of the alleles among patients with allergic inflammatory disorders and among 50 prospectively...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.