Cutting edge: dominant effect of Ile50Val variant of the human IL-4 receptor alpha-chain in IgE synthesis.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Cutting edge: dominant effect of Ile50Val variant of the human IL-4 receptor alpha-chain in IgE synthesis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1999

Mitsuyasu H, Yanagihara Y, Mao X Q, Gao P S, Arinobu Y, Ihara K, Takabayashi A, Hara T, Enomoto T, Sasaki S, Kawai M, Hamasaki N, Shirakawa T, Hopkin J M, Izuhara K

Abstract excerpt

Two variants of the IL-4R alpha-chain (IL-4Ralpha) gene have been recently identified in association with different atopic disorders. To clarify the etiological relationship between the two variants, we analyzed responsiveness to IL-4 of transfectants with four kinds of IL-4Ralpha carrying either...

Topics

Amino Acid Substitution
Animals
B-Lymphocytes
Base Sequence
Cell Line
Genetic Variation
Humans
Hypersensitivity, Immediate
Immunoglobulin E
Mice
Mutagenesis, Site-Directed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotide Probes

Promoter Regions, Genetic

Protein Conformation

Receptors, IgE

Receptors, Interleukin-4

Recombinant Proteins

STAT6 Transcription Factor

Source

Open in PubMed

Identifiers

PMID: 9973373

Genes

STAT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9973373-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cutting edge: dominant effect of Ile50Val variant of the human IL-4 receptor alpha-chain in IgE synthesis.PMID 9973373Read ↗

Cutting Edge: Dominant Effect of Ile50Val Variant of the Human IL-4 Receptor α-Chain in IgE SynthesisSemantic proximity Read ↗

Atopy and the human IL-4 receptor alpha chain.Semantic proximity Read ↗

An IL-4R alpha allelic variant, I50, acts as a gain-of-function variant relative to V50 for Stat6, but not Th2 differentiation.Semantic proximity Read ↗

Gene-gene interaction between interleukin-4 and interleukin-4 receptor alpha in Korean children with asthma.Semantic proximity Read ↗

Ile50Val variant of IL4Rα upregulates IgE synthesis and associates with atopic asthmaSemantic proximity Read ↗

Analysis of the Ser786Pro interleukin-4 receptor alpha allelic variant in allergic and nonallergic asthma and its functional consequences.Semantic proximity Read ↗

Polymorphisms in the Fc epsilon RI beta promoter region affecting transcription activity: a possible promoter-dependent mechanism for association between Fc epsilon RI beta and atopy.Semantic proximity Read ↗

Effects of common atopy-associated amino acid substitutions in the IL-4 receptor alpha chain on IL-4 induced phenotypes.Semantic proximity Read ↗

Genetic variants of IL-13 signalling and human asthma and atopy.Semantic proximity Read ↗

The polymorphisms S503P and Q576R in the interleukin-4 receptor alpha gene are associated with atopy and influence the signal transduction.Semantic proximity Read ↗

A novel -66T/C polymorphism in Fc epsilon RI alpha-chain promoter affecting the transcription activity: possible relationship to allergic diseases.Semantic proximity Read ↗

Childhood Atopic Asthma: Positive Association with a Polymorphism of IL-4 Receptor α Gene but Not with That of IL-4 Promoter or Fc ε Receptor I β GeneSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.