Article
Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma.
The Journal of experimental medicine - 28 Sept 2009
Tachdjian Raffi, Mathias Clinton, Al Khatib Shadi, Bryce Paul J, Kim Hong S, Blaeser Frank, O'Connor Brian D, Rzymkiewicz Danuta, Chen Andrew, Holtzman Michael J, Hershey Gurjit K, Garn Holger, Harb Hani, Renz Harald, Oettgen Hans C, Chatila Talal A
Abstract excerpt
Polymorphisms in the interleukin-4 receptor alpha chain (IL-4R alpha) have been linked to asthma incidence and severity, but a causal relationship has remained uncertain. In particular, a glutamine to arginine substitution at position 576 (Q576R) of IL-4R alpha has been associated with severe asthma, especially in African Americans. We show that mice carrying the Q576R polymorphism exhibited intense...
Topics
- Alleles
- Animals
- Asthma
- Humans
- Immunoglobulin E
- Interleukin-13
- Interleukin-4
- Mice
- Mice, Transgenic
- Mutation
- Ovalbumin