Article

Cutting Edge: Dominant Effect of Ile50Val Variant of the Human IL-4 Receptor α-Chain in IgE Synthesis

1999-02-01

Abstract excerpt

Abstract Two variants of the IL-4R α-chain (IL-4Rα) gene have been recently identified in association with different atopic disorders. To clarify the etiological relationship between the two variants, we analyzed responsiveness to IL-4 of transfectants with four kinds of IL-4Rα carrying either Val or Ile at 50 and either Gln or Arg at 551. The substitution of Ile for Val augmented STAT6 activation, proliferation,...

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Literature Corpus work: ab2f2be0-0249-5e5f-9e43-76b324efff55
DOI: 10.4049/jimmunol.162.3.1227

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Cutting Edge: Dominant Effect of Ile50Val Variant of the Human IL-4 Receptor α-Chain in IgE SynthesisDOI 10.4049/jimmunol.162.3.1227Read

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