Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of common atopy-associated amino acid substitutions in the IL-4 receptor alpha chain on IL-4 induced phenotypes.

Immunogenetics - 1 Feb 2005

Franjkovic Izolda, Gessner Andre, König Inke, Kissel Karin, Bohnert Anette, Hartung Anne, Ohly Astrid, Ziegler Andreas, Hackstein Holger, Bein Gregor

Abstract excerpt

The human IL-4 receptor alpha chain gene (IL4R) is highly polymorphic and controversial reports have been published with respect to the association of different single nucleotide polymorphisms (SNPs) with atopy markers. Here we analyzed the functional and associational relevance of common IL4R coding SNPs. Transfection of B cell lines expressing the IL-4R variant V75+R576 did not result in enhanced IL-4 induced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to B-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hypersensitivity, Immediate

Share to Immunoglobulin E

Share to Interleukin-4

Share to Receptors, Interleukin-4

Share to T-Lymphocytes

Share to Transfection

Source

Identifiers

PMID: 15712015
DOI: 10.1007/s00251-004-0763-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of common atopy-associated amino acid substitutions in the IL-4 receptor alpha chain on IL-4 induced phenotypes.PMID 15712015Read ↗

The polymorphisms S503P and Q576R in the interleukin-4 receptor alpha gene are associated with atopy and influence the signal transduction.Semantic proximity Read ↗

The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor.Semantic proximity Read ↗

An IL-4R alpha allelic variant, I50, acts as a gain-of-function variant relative to V50 for Stat6, but not Th2 differentiation.Semantic proximity Read ↗

V75R576 IL-4 receptor alpha is associated with allergic asthma and enhanced IL-4 receptor function.Semantic proximity Read ↗

Cutting Edge: Dominant Effect of Ile50Val Variant of the Human IL-4 Receptor α-Chain in IgE SynthesisSemantic proximity Read ↗

Analysis of the Ser786Pro interleukin-4 receptor alpha allelic variant in allergic and nonallergic asthma and its functional consequences.Semantic proximity Read ↗

Polymorphisms in the interleukin-4 receptor alpha chain: association with traits of allergy and asthma in an admixed population in Hawaii.Semantic proximity Read ↗

Atopy and the human IL-4 receptor alpha chain.Semantic proximity Read ↗

A comprehensive analysis of interleukin-4 receptor polymorphisms and their association with atopy and IgE regulation in childhood.Semantic proximity Read ↗

Sequence variants in the FcepsilonRI alpha chain gene.Semantic proximity Read ↗

Cutting edge: dominant effect of Ile50Val variant of the human IL-4 receptor alpha-chain in IgE synthesis.Semantic proximity Read ↗

No linkage or association of five polymorphisms in the interleukin-4 receptor alpha gene with atopic asthma in Italian families.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.