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Article

Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation.

The Journal of experimental medicine - 20 Oct 2003

Blaeser Frank, Bryce Paul J, Ho Nga, Raman Vidya, Dedeoglu Fatma, Donaldson Debra D, Geha Raif S, Oettgen Hans C, Chatila Talal A

Abstract excerpt

The insulin/interleukin-4 (IL-4) receptor (I4R) motif mediates the association of insulin receptor substrate (IRS)-2 with the interleukin-4 (IL-4)Ralpha chain and transduces mitogenic signals in response to IL-4. Its physiological functions were analyzed in mice with a germline point mutation that changed the motif's effector tyrosine residue into phenylalanine (Y500F). The Y500F mutation abrogated IRS-2...

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Identifiers

PMID: 14557412
DOI: 10.1084/jem.20030471
PMCID: PMC2194235

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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