Article
Analysis of the Ser786Pro interleukin-4 receptor alpha allelic variant in allergic and nonallergic asthma and its functional consequences.
Clinical immunology (Orlando, Fla.) - 1 Sept 2001
Andrews R P, Burrell L, Rosa-Rosa L, Cunningham C M, Brzezinski J L, Bernstein J A, Khurana Hershey G K
Abstract excerpt
Asthma and other atopic disorders affect a large percentage of the population. While many factors contribute to the phenotype of asthma, there is a strong genetic predisposition. IL-4 is a central mediator of allergic inflammation. Along with IL-13, it is the major cytokine responsible for the induction of IgE synthesis. Furthermore, IL-4 acts on Th0 cells and promotes their differentiation into Th2 cells...
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