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Article

Perturbed homeostasis of peripheral T cells elicits decreased susceptibility to anti-CD3-induced apoptosis in prediabetic nonobese diabetic mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2004

Yang Wen, Hussain Shabbir, Mi Qing-Sheng, Santamaria Pere, Delovitch Terry L

Abstract excerpt

Activation-induced cell death (AICD) plays a key role in the homeostasis of the immune system. Autoreactive T cells are eliminated through AICD both from the thymus and periphery. In this study, we show that NOD peripheral T cells, especially CD8(+) T cells, display a decreased susceptibility to anti-CD3-induced AICD in vivo compared with T cells from diabetes-resistant B6, nonobese diabetes-resistant, and...

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Source

Identifiers

PMID: 15383571
DOI: 10.4049/jimmunol.173.7.4407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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