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Article

Significant role for Fas in the pathogenesis of autoimmune diabetes.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2000

Su X, Hu Q, Kristan J M, Costa C, Shen Y, Gero D, Matis L A, Wang Y

Abstract excerpt

Programmed cell death represents an important pathogenic mechanism in various autoimmune diseases. Type I diabetes mellitus (IDDM) is a T cell-dependent autoimmune disease resulting in selective destruction of the beta cells of the islets of Langerhans. beta cell apoptosis has been associated with IDDM onset in both animal models and newly diagnosed diabetic patients. Several apoptotic pathways have been...

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PMID: 10679090
DOI: 10.4049/jimmunol.164.5.2523

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Significant role for Fas in the pathogenesis of autoimmune diabetes.PMID 10679090Read ↗

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Protection from autoimmune diabetes and T-cell lymphoproliferation induced by FasL mutation are differentially regulated and can be uncoupled pharmacologically.Semantic proximity Read ↗

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