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Article

Apoptosis resistance of nonobese diabetic peripheral lymphocytes linked to the Idd5 diabetes susceptibility region.

Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 1997

Colucci F, Bergman M L, Penha-Gonçalves C, Cilio C M, Holmberg D

Abstract excerpt

Defects in lymphocyte apoptosis may lead to autoimmune disorders and contribute to the pathogenesis of type 1 diabetes. Lymphocytes of nonobese diabetic (NOD) mice, an animal model of autoimmune diabetes, have been found resistant to various apoptosis signals, including the alkylating drug cyclop...

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Identifiers

PMID: 9238035
DOI: 10.1073/pnas.94.16.8670
PMCID: PMC23070

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9238035-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Apoptosis resistance of nonobese diabetic peripheral lymphocytes linked to the Idd5 diabetes susceptibility region.PMID 9238035Read ↗

Type 1 diabetes and the control of dexamethazone-induced apoptosis in mice maps to the same region on chromosome 6.Semantic proximity Read ↗

Diabetes protection and restoration of thymocyte apoptosis in NOD Idd6 congenic strains.Semantic proximity Read ↗

Role of defective apoptosis in type 1 diabetes and other autoimmune diseases.Semantic proximity Read ↗

Central role of defective apoptosis in autoimmunity.Semantic proximity Read ↗

Perturbed homeostasis of peripheral T cells elicits decreased susceptibility to anti-CD3-induced apoptosis in prediabetic nonobese diabetic mice.Semantic proximity Read ↗

Implications of altered apoptosis in diabetes mellitus and autoimmune disease.Semantic proximity Read ↗

Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling.Semantic proximity Read ↗

Susceptibility to lymphoid neoplasia in immunodeficient strains of nonobese diabetic mice.Semantic proximity Read ↗

Subcongenic analyses reveal complex interactions between distal chromosome 4 genes controlling diabetogenic B cells and CD4 T cells in nonobese diabetic mice.Semantic proximity Read ↗

The circadian gene Arntl2 on distal mouse chromosome 6 controls thymocyte apoptosis.Semantic proximity Read ↗

The idd4 locus displays sex-specific epistatic effects on type 1 diabetes susceptibility in nonobese diabetic mice.Semantic proximity Read ↗

NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.Semantic proximity Read ↗

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