Article

Excessive apoptosis of naïve T cells resulting hyperactivation as a cause of mammalian aging

2023-02-26

Abstract excerpt

In mammals, the most remarkable T cell variations with aging are the shrinking of naïve T cell pool and enlargement of memory T cell pool, which are partially caused by thymic involution. However, it remains an enigma whether these T-cell-related changes are consequences or causes of mammalian aging. In this study, we find that the T-cell specific Rip1 KO mice present similar age-related T cell changes and exhibi...

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Literature Corpus work: 9c91fa70-13d3-5527-93ce-e5fcddadd13a
DOI: 10.1101/2023.02.24.529806

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