Article
A defect in central tolerance in NOD mice.
Nature immunology - 1 Nov 2001
Kishimoto H, Sprent J
Abstract excerpt
The predisposition of nonobese diabetic (NOD) mice to develop autoimmune disease is usually attributed to defects in peripheral tolerance mechanisms. Here, evidence is presented that NOD mice display a defect in central tolerance (negative selection) of thymocytes. Impaired central tolerance in NOD mice was most prominent in a population of semi-mature thymocytes found in the medulla. The defect was apparent in...
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