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Article

Control of axonal branching and synapse formation by focal adhesion kinase.

Nature neuroscience - 1 Oct 2004

Rico Beatriz, Beggs Hilary E, Schahin-Reed Dorreyah, Kimes Nikole, Schmidt Andrea, Reichardt Louis F

Abstract excerpt

The formation of neuronal networks in the central nervous system (CNS) requires precise control of axonal branch development and stabilization. Here we show that cell-specific ablation of the murine gene Ptk2 (more commonly known as fak), encoding focal adhesion kinase (FAK), increases the number of axonal terminals and synapses formed by neurons in vivo. Consistent with this, fak mutant neurons also form greater...

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Identifiers

PMID: 15378065
DOI: 10.1038/nn1317
PMCID: PMC2711902

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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