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Article

Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development.

Neuron - 22 Mar 2012

Ultanir Sila K, Hertz Nicholas T, Li Guangnan, Ge Woo-Ping, Burlingame Alma L, Pleasure Samuel J, Shokat Kevan M, Jan Lily Yeh, Jan Yuh-Nung

Abstract excerpt

Dendrite arborization and synapse formation are essential for wiring the neural circuitry. The evolutionarily conserved NDR1/2 kinase pathway, important for polarized growth from yeast to mammals, controls dendrite growth and morphology in the worm and fly. The function of NDR1/2 in mammalian neurons and their downstream effectors were not known. Here we show that the expression of dominant negative (kinase-dead)...

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Identifiers

PMID: 22445341
DOI: 10.1016/j.neuron.2012.01.019
PMCID: PMC3333840

Genes

AAK1

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