Article
RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK.
Cellular signalling - 1 Jan 2014
Dwane Susan, Durack Edel, O'Connor Rosemary, Kiely Patrick A
Abstract excerpt
RACK1 binds proteins in a constitutive or transient manner and supports signal transmission by engaging in diverse and distinct signalling pathways. The emerging theme is that RACK1 functions as a signalling switch, recruiting proteins to form distinct molecular complexes. In focal adhesions, RACK1 is required for the regulation of FAK activity and for integrating a wide array of cellular signalling events...
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