Article
Focal adhesion kinase promotes integrin adhesion dynamics necessary for chemotropic turning of nerve growth cones.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 Sept 2011
Myers Jonathan P, Gomez Timothy M
Abstract excerpt
The ability of extending axons to navigate using combinations of extracellular cues is essential for proper neural network formation. One intracellular signaling molecule that integrates convergent signals from both extracellular matrix (ECM) proteins and growth factors is focal adhesion kinase (FAK). Analysis of FAK function shows that it influences a variety of cellular activities, including cell motility,...
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