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Article

FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies.

Neuron - 30 Oct 2003

Beggs Hilary E, Schahin-Reed Dorreyah, Zang Keling, Goebbels Sandra, Nave Klaus Armin, Gorski Jessica, Jones Kevin R, Sretavan David, Reichardt Louis F

Abstract excerpt

Targeted deletion of focal adhesion kinase (fak) in the developing dorsal forebrain resulted in local disruptions of the cortical basement membrane located between the neuroepithelium and pia-meninges. At disruption sites, clusters of neurons invaded the marginal zone. Retraction of radial glial endfeet, midline fusion of brain hemispheres, and gliosis also occurred, similar to type II cobblestone lissencephaly...

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Identifiers

PMID: 14642275
DOI: 10.1016/s0896-6273(03)00666-4
PMCID: PMC2758566

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies.PMID 14642275Read ↗

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