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Article

Rac GTPases control axon growth, guidance and branching.

Nature - 28 Mar 2002

Ng Julian, Nardine Timothy, Harms Matthew, Tzu Julia, Goldstein Ann, Sun Yan, Dietzl Georg, Dickson Barry J, Luo Liqun

Abstract excerpt

Growth, guidance and branching of axons are all essential processes for the precise wiring of the nervous system. Rho family GTPases transduce extracellular signals to regulate the actin cytoskeleton. In particular, Rac has been implicated in axon growth and guidance. Here we analyse the loss-of-function phenotypes of three Rac GTPases in Drosophila mushroom body neurons. We show that progressive loss of combined...

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Identifiers

PMID: 11919635
DOI: 10.1038/416442a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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