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Understanding the Roles of FAK in Cancer

7 Nov 2014

Abstract excerpt

Focal adhesion kinase (FAK) is a protein tyrosine kinase that regulates cellular adhesion, motility, proliferation and survival in various types of cells. Interestingly, FAK is activated and/or overexpressed in advanced cancers, and promotes cancer progression and metastasis. For this reason, FAK became a potential therapeutic target in cancer, and small molecule FAK inhibitors have been developed and are being...

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PMID: 25380750
DOI: 10.1369/0022155414561498

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