Article
Neurofibromin mediates FAK signaling in confining synapse growth at Drosophila neuromuscular junctions.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 Nov 2012
Tsai Pei-I, Wang Manyu, Kao Hsiu-Hua, Cheng Ying-Ju, Walker James A, Chen Ruey-Hwa, Chien Cheng-Ting
Abstract excerpt
Neurofibromatosis type I (NF1), caused by the mutation in the NF1 gene, is characterized by multiple pathological symptoms. Importantly, ~50% of NF1 patients also suffer learning difficulty. Although downstream pathways are well studied, regulation of the NF1-encoded neurofibromin protein is less clear. Here, we focused on the pathophysiology of Drosophila NF1 mutants in synaptic growth at neuromuscular...
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