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Article

Abundant Focal Adhesion Kinase Causes Aberrant Neuronal Migration Via Its Phosphorylation at Tyr925.

Journal of molecular neuroscience : MN - 1 Jan 2018

An Lei, Li Weiwei, Hu Xinde, Zhang Wei, Zhao Shanting

Abstract excerpt

The process of neuronal migration is precisely regulated by different molecules during corticogenesis. The FAK (focal adhesion kinase) plays a critical role in embryogenesis and is involved in cell motility through focal adhesions, but the underlying mechanisms on inordinate expression are unclear. To investigate the effect of FAK overexpression on neuronal migration spatiotemporally, mice FAK was transfected...

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PMID: 29209901
DOI: 10.1007/s12031-017-1010-1

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