Article
Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice.
European journal of immunology - 1 Feb 1992
Sidman C L, Marshall J D, Von Boehmer H
Abstract excerpt
To investigate the role of T cell receptor (TcR) expression and interactions in development of lymphoproliferation and autoimmunity in lpr and gld mutant mice, and to determine whether these autoimmune mutations affect T cell selection and repertoire formation, we generated mice homozygous for either the gld or the lpr mutation and containing TcR alpha/beta transgenes (Von Boehmer, H., Annu. Rev. Immunol. 1990....
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