Article
Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice.
European journal of immunology - 1 Feb 1992
Sidman C L, Marshall J D, Von Boehmer H
Abstract excerpt
To investigate the role of T cell receptor (TcR) expression and interactions in development of lymphoproliferation and autoimmunity in lpr and gld mutant mice, and to determine whether these autoimmune mutations affect T cell selection and repertoire formation, we generated mice homozygous for ei...
Topics
- Alleles
- Animals
- Autoimmune Diseases
- Flow Cytometry
- H-2 Antigens
- H-Y Antigen
- Lymphoproliferative Disorders
- Major Histocompatibility Complex
- Mice
- Mice, Mutant Strains
- Mice, Transgenic
- Receptors, Antigen, T-Cell
- T-Lymphocyte Subsets