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Article

Tetraparental mice reveal complex cellular interactions of the mutant, autoimmunity-inducing lpr gene.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 1992

Katagiri T, Azuma S, Toyoda Y, Mori S, Kano K, Cohen P L, Eisenberg R A

Abstract excerpt

Lpr is a murine recessive autosomal mutant gene that, in conjunction with the background genes of different inbred mouse strains, produces varied syndromes of lymphadenopathy and autoantibody production. We have investigated the cellular basis of the lpr determined phenomena by constructing allophenic (tetraparental) chimeras of MRL/Mp-lpr/lpr combined with C57BL/6 and MRL/+ combined with C57BL/6-lpr/lpr. The...

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PMID: 1729363

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