Tetraparental mice reveal complex cellular interactions of the mutant, autoimmunity-inducing lpr gene.

Article

Tetraparental mice reveal complex cellular interactions of the mutant, autoimmunity-inducing lpr gene.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 1992

Katagiri T, Azuma S, Toyoda Y, Mori S, Kano K, Cohen P L, Eisenberg R A

Abstract excerpt

Lpr is a murine recessive autosomal mutant gene that, in conjunction with the background genes of different inbred mouse strains, produces varied syndromes of lymphadenopathy and autoantibody production. We have investigated the cellular basis of the lpr determined phenomena by constructing allop...

Topics

Animals
Autoantibodies
Autoimmune Diseases
Chimera
Genes
Immunoglobulin G
Immunoglobulin M
Lymphocytes
Lymphoproliferative Disorders
Mice
Mice, Inbred ICR
Mutation

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